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KMID : 0370220190630050297
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Yakhak Hoeji
2019 Volume.63 No. 5 p.297 ~ p.302
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Fabrication of Theophylline-loaded Sustained Release Tablet via Coupling of Hot Melt Extrusion and 3D Printing
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Son Eon-Soo
Seo Young-Jun
Kim Dong-Wuk
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Abstract
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The objective of this study was to develop a new approach for fabrication of 3D printed tablet containing active pharmaceutical ingredients (APIs), exploiting the hot-melt extrusion (HME) coupled with 3D printing technology. Theophylline was used as a model drug, and hydroxypropyl cellulose (HPC), hydroxypropyl methylcellulose (HPMC) and stearic acid (SA) were used as a carrier or plasticizer for the preparation of drug-loaded filaments. Four different compositions were hot-melt extruded, and three of them available for 3D printing showed a zero-order sustained release over 9 hours. Overall, 3DP technology coupled with HME could be a novel method to produce controlled release tablets providing the advantage of simplicity and versatility than the conventional method.
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KEYWORD
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hydroxypropyl cellulose, hydroxypropyl methylcellulose, theophylline, hot-melt extrusion, fused deposition modeling 3D printing
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